Transit Gateway peering enables cross-region connectivity, and route tables can steer traffic for inspection.
Why this answer
It uses Transit Gateway inter-region peering to connect the two regions, and by attaching an inspection VPC (with a firewall) in us-east-1 to the Transit Gateway, you can route all inter-region traffic through that VPC for inspection. The Transit Gateway route tables in each region are configured to send traffic destined for the other region to the inspection VPC attachment, ensuring traffic is inspected before being forwarded.
Exam trap
The trap here is that candidates often confuse VPC peering (which is non-transitive) with Transit Gateway peering (which supports transitive routing through inspection VPCs), leading them to select Option C incorrectly.
How to eliminate wrong answers
Option A is wrong because establishing a VPN connection between the two VPCs does not inherently provide traffic inspection through a firewall in us-east-1; it would require complex manual routing and does not leverage Transit Gateway for centralized inspection. Option C is wrong because VPC peering does not support transitive routing, so you cannot route traffic through an inspection VPC in us-east-1; traffic would flow directly between the peered VPCs without inspection. Option D is wrong because a Direct Connect gateway is used for connecting on-premises networks to VPCs, not for inter-region VPC connectivity, and it does not provide a mechanism for traffic inspection between regions.