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350-701Chapter 17 of 18Objective 6.1

Endpoint Protection and Cisco AMP

How do you stop a piece of malicious software that has never been seen before from infecting a laptop on your network? That’s the exact problem Cisco AMP for endpoints solves, and why it’s a major topic on the 350-701 exam. This chapter explains endpoint protection concepts and how Cisco’s Advanced Malware Protection (AMP) works to defend individual devices—laptops, servers, even smartphones—from modern threats.

12 min read
Intermediate
Updated Jul 23, 2026
Reviewed by Johnson Ajibi· Senior Network & Security Engineer · MSc IT Security

A simple way to picture Endpoint Protection and Cisco AMP

The House Sitter and the Security Camera Analogy

Your house, the one you’ve spent years filling with your stuff. You’re going on holiday for two weeks.

Before you leave, you hire a house sitter. This is your basic security: someone physically there to unlock the door when you come back and maybe call the police if they see a broken window. But the sitter is human: they get bored, they miss things, they might not spot the tiny crack in the back fence where someone could slip in. That’s what traditional antivirus software is like—it sits on your computer and waits for a known bad guy to knock on the front door.

Now imagine a better system. You install eight cameras around your house, all linked to a mobile app on your phone. The cameras don’t just record—they analyse. One camera sees a squirrel and ignores it. Another spots a person loitering by the garage at 3 a.m., sends you a clip, and locks the back gate automatically. A third camera, monitoring your Wi-Fi signal, detects an unknown device trying to connect to your smart thermostat and blocks it instantly. This is Cisco AMP for endpoints. It doesn’t just wait for a known virus (a known criminal). It watches for unusual behaviour—a program trying to change system files, a laptop suddenly sending data to a foreign server—and stops it before damage is done. And because the cameras are all linked (in the cloud), if a neighbour’s house gets broken into, your system updates its rules to watch for that same trick. You’re protected even while you’re miles away. The sitter is still there, but the smart cameras are what really keep your house safe.

How It Actually Works

Let’s start with the basics. An endpoint is any device that connects to a network. That includes your laptop, your desktop computer, a server, a smartphone, a tablet, or even a smart thermostat. In IT security, we call these ‘endpoints’ because they sit at the end of the network connection, where people actually use them. Endpoint protection is the practice of securing each of these devices against malware, unauthorised access, and data theft.

In the old days, endpoint protection meant installing a single piece of software called antivirus (AV). Traditional AV works using signatures. A signature is like a digital fingerprint of a known piece of malware. The software has a big list of these fingerprints, and whenever you open a file, it checks the file’s fingerprint against the list. If there’s a match, the file is blocked or quarantined. This worked well for a long time, but it has a huge weakness: it can only stop malware that has already been seen and catalogued. New or custom-written malware has no signature, so it slips right through.

Cisco AMP for endpoints is a different, smarter approach. AMP stands for Advanced Malware Protection. It uses three main methods: telemetry, analysis, and retrospective security.

First, telemetry means the software collects massive amounts of information about every process running on the endpoint—not just files, but also behaviour, network connections, and system changes. This data is sent to Cisco’s cloud-based analysis engine. Second, analysis uses several techniques to decide if something is malicious. The primary technique is file reputation. Every file that executes is given a reputation score based on where it came from, its age, its digital signature, and thousands of other factors. A file downloaded from a well-known software vendor’s site gets a good reputation; a file from a suspicious IP address gets a bad one. But AMP also uses behavioural analysis. It watches what the file does once it runs. If a Word document suddenly tries to access the Windows registry and then starts sending emails, AMP recognises that as unusual behaviour, even if the Word document looks completely clean based on its signature.

Third, and most importantly, AMP uses retrospective security. This is its killer feature. Imagine AMP allows a file to run because its reputation score is acceptable and its behaviour seems normal. Later, Cisco’s threat intelligence team might discover that the file was actually malicious all along. With retrospective security, AMP goes back in time, identifies every endpoint that ever touched that file, and tells you exactly what happened: where the file came from, which endpoints it spread to, and what it did. Then you can take action, like rolling back the file to a clean state, even weeks after the infection started. Old antivirus could never do that.

Cisco AMP for endpoints runs as a lightweight software agent on each device. It communicates with the AMP cloud using an encrypted connection. The cloud stores the telemetry data, performs the analysis, and sends back verdicts—‘clean’, ‘malicious’, or ‘unknown’—to the agent. The agent then enforces the verdict by blocking, quarantining, or allowing the file.

AMP also includes orbital, a built-in advanced search tool that lets an IT professional query all their endpoints at once. For example, you could search for any endpoint that has a specific registry key or a particular version of a driver, without needing to log into each machine individually.

Why does this matter for the 350-701 exam? The exam explicitly tests your understanding of endpoint protection concepts and how AMP differs from traditional signature-based AV. You need to know what telemetry, file reputation, behavioural analysis, and retrospective security mean. You also need to understand the deployment options: AMP can be installed as a standalone product on endpoints, or it can be integrated with other Cisco security products like Cisco Umbrella (for web security) and Cisco Firepower (for network firewalls). Both Cisco AMP and Cisco Firepower use the same threat intelligence intelligence, so detection improves across the whole network.

In short, endpoint protection with AMP moves from reactive defence (waiting for a known signature) to proactive defence (analysing behaviour and using cloud intelligence to catch novel threats). For the exam, remember the key differences: signatures versus behaviour, local detection versus cloud analysis, and retrospective versus forward-only visibility.

Here are the main features that Cisco AMP for endpoints provides:

File reputation: Every file is scored based on its characteristics and history.

Behavioural analysis: Actions of a running process are monitored for suspicious patterns.

Retrospective security: After an initial verdict, AMP can re-evaluate and roll back threats.

Orbital search: A query system to hunt for indicators across all endpoints.

Integration: AMP works with Cisco Umbrella, Firepower, and Identity Services Engine (ISE).

This diagram shows how the AMP agent on an endpoint communicates with the AMP cloud, which uses threat intelligence to return verdicts and supports retrospective updates.

Walk-Through

1

Install the AMP for Endpoints Connector

You deploy the lightweight AMP agent software to each device you want to protect. This can be done manually, via a software deployment tool like Microsoft SCCM, or through a mobile device management solution. The agent is the piece that collects telemetry and enforces policies.

2

Agent Connects to the AMP Cloud

Upon installation, the agent establishes an encrypted HTTPS connection to the Cisco AMP cloud. It authenticates using a unique connector ID and shares basic system information. The cloud maintains the central policy and threat intelligence.

3

File Executes and is Analysed

When a user opens a file or a program runs, the agent computes a cryptographic hash (like SHA-256) of the file. It sends this hash, along with metadata (file name, size, source path), to the AMP cloud. The cloud checks file reputation, behavioural history, and global prevalence.

4

Verdict is Returned and Enforced

The cloud returns a verdict: clean, malicious, or unknown. If malicious, the agent blocks the file from executing and quarantines it. If unknown, the agent may allow it to run but continues to watch its behaviour. The agent uploads any suspicious behavioural events back to the cloud for deeper analysis.

5

Retrospective Analysis and Remediation

Days or weeks later, Cisco’s threat intelligence may update the verdict on a previously allowed file. The cloud sends a retrospective alert to all agents that ran that file. The agent automatically quarantines the file and, if configured, removes associated persistence mechanisms (like registry keys or scheduled tasks). The analyst can see the full infection timeline in the console.

6

Hunt and Investigate with Orbital

If a new indicator of compromise (IOC) emerges, the analyst can use orbiral to search across all endpoints for a specific file hash, process name, or registry key. Orbital runs a live query in seconds and returns results from all connected machines, enabling rapid incident response.

What This Looks Like on the Job

Imagine you work as an IT security analyst for a medium-sized company with 500 employees, all using laptops running Windows and macOS. One Tuesday morning, you get an alert from Cisco AMP. The alert says that a file called ‘invoice_april.pdf.exe’ was blocked on three laptops in the finance department. The file had a very low reputation score because it was downloaded from a website registered only 24 hours ago. AMP blocked it before it could execute.

Step one: you open the AMP console in your browser. The console shows a timeline of events for each affected laptop. You see that the file arrived as an email attachment. The email looked like it came from the CEO’s account, but the sender address was spoofed (forged). Because the executives in finance don’t have the required permissions to approve a new payment, they forwarded the email to someone who does. AMP blocked the file on the first machine, but the attacker had sent the same email to multiple people, so three other machines also received it.

Step two: you use the ‘orbital’ search feature to find if any other endpoint downloaded a file from the same URL or received an email with a similar subject line. Orbital returns results from 12 other machines, all from different departments. You see that nine of those machines had the file blocked, but three machines had the file allowed because their reputation databases were slightly delayed (they hadn’t yet received the updated threat feed). Those three machines are now infected.

Step three: you use AMP’s retrospective security to trace what happened on those three infected machines. The cloud shows that the malicious PDF executable ran, created a new user account with administrative privileges, and then tried to contact an external control server. AMP had already flagged that connection attempt as malicious, so even though the file was allowed to run initially, AMP blocked the outbound network connection. The attack failed to exfiltrate (steal) any data.

Step four: you take action. You use AMP to quarantine the affected files on all three machines. AMP also lists the registry keys and persistence mechanisms the malware created. You manually remove those from each system, or you use a scripting tool to automate the cleanup across all affected endpoints.

Step five: you block the sender’s email address at the email gateway and block the download URL at your firewall, which also has Cisco Firepower. Because AMP and Firepower share threat intelligence, the block is automatically applied to all future traffic.

What you did as an IT professional:

You monitored alerts in the AMP console.

You investigated the scope of the threat using orbiral search.

You used retrospective security to understand the full attack chain.

You remediated the infection by quarantining files and removing persistence.

You updated your security controls to prevent future attacks.

Without AMP, you would have had no visibility into the email, no way to know which machines had the file, and no way to roll back the infection on the three machines that were initially compromised. You would have had to reimage (wipe and reinstall) all 15 machines, costing hours of work and significant productivity loss.

For the exam, remember this scenario: AMP gives you visibility, retrospective detection, and automated response. You are expected to know the difference between AMP’s behaviour and traditional AV.

How 350-701 Actually Tests This

The 350-701 exam tests you on endpoint protection concepts and Cisco AMP for endpoints in several ways. Expect multiple-choice questions that ask you to identify the correct definition or the purpose of a specific AMP feature.

First, you will see questions about the core differences between traditional antivirus (AV) and AMP. The exam loves asking: ‘Which of the following is a limitation of signature-based antivirus?’ The correct answer is always something like ‘It cannot detect unknown or zero-day malware because it relies on known signatures.’ Traps include saying it’s slow, or that it uses too much memory—those are not the fundamental limitation. The true limitation is that signatures are reactive.

Second, expect questions about telemetry. You might be asked: ‘What type of data does the AMP endpoint agent send to the cloud?’ The answer is telemetry data, which includes file hashes, process metadata, and behavioural observations. A common trap is ‘log files’ or ‘complete file contents’ — AMP does not send entire files to the cloud (that would consume too much bandwidth). It sends metadata and a cryptographic hash (a unique fingerprint) of the file.

Third, file reputation is a favourite topic. They might ask: ‘What is the purpose of a file reputation score?’ The answer: to determine the trustworthiness of a file based on its characteristics and history. They will try to confuse you by saying it’s based on the file’s size or creation date only. The correct answer is that it uses multiple factors including source, digital signature, age, and global prevalence.

Fourth, retrospective security is almost certainly tested. A typical question: ‘An analyst sees that a file was allowed to execute, but 48 hours later the verdict changes to malicious. How can the analyst respond?’ The correct answer: use retrospective security to see which endpoints touched the file and take remediation action. The trap is to suggest that you must manually scan each endpoint or reimage all machines. AMP automates the rollback.

Fifth, they may ask about deployment and integration. Questions like: ‘Which Cisco product can integrate with AMP to provide network-based protection?’ The answer is Cisco Firepower or Cisco Umbrella. The trap is to list a product that doesn’t integrate, like Cisco ISE (which does identity, not malware protection). Know that AMP shares threat intelligence with Firepower and Umbrella.

Sixth, there will be questions about the AMP agent itself. For example: ‘What protocol does the AMP agent use to communicate with the cloud?’ The answer is HTTPS (encrypted web traffic). The trap is ‘HTTP’ (unencrypted) or ‘SMTP’ (email). Always choose the secure protocol.

Seventh, the exam may test your understanding of zero-day malware. A zero-day exploit is an attack that uses a vulnerability not yet known to the vendor. AMP can detect zero-day malware using behavioural analysis, even without a signature. Expect a question like: ‘Which AMP feature best detects zero-day malware?’ Answer: behavioural analysis or file reputation, not signature detection.

Finally, memorise the following concepts for the exam:

Endpoint: any device connecting to a network.

Signature: a file fingerprint used by traditional AV.

Telemetry: data about system activity sent to the cloud.

File reputation: a trust score for files.

Behavioural analysis: monitoring what a file does when it runs.

Retrospective security: re-evaluating past events after new threat info.

Orbital: a live search tool for endpoints.

AMP cloud: the central analysis and management platform.

The exam will not ask you to configure AMP. It will ask you to describe what it does and why it’s better than traditional methods. Focus on concepts and high-level capabilities.

Key Takeaways

Cisco AMP for endpoints uses file reputation, behavioural analysis, and cloud-based threat intelligence to detect and block malware, not just static signatures.

Retrospective security allows AMP to change its verdict on a file after it has executed and then automatically remediate all affected endpoints.

AMP sends telemetry (metadata and behavioural data) to the cloud, not the full file content, which keeps network bandwidth usage low.

AMP integrates with Cisco Firepower and Cisco Umbrella to share threat intelligence across network and endpoint layers.

The AMP agent runs on Windows, macOS, Linux, Android, and iOS devices.

Orbital is a live search tool that lets analysts query every managed endpoint for specific files, processes, or registry keys in real time.

Traditional signature-based antivirus cannot detect zero-day malware, but AMP’s behavioural analysis can identify suspicious activity even for new threats.

Easy to Mix Up

These come up on the exam all the time. Here's how to tell them apart.

Traditional Antivirus (Signature-based)

Relies solely on known malware signatures (file fingerprints)

Detection only works if the signature is already in the local database

Cannot detect zero-day or custom malware

Cisco AMP (Cloud-based)

Uses file reputation, behavioural analysis, and cloud intelligence

Can detect unknown threats through behavioural anomaly detection

Uses retrospective security to catch threats after first execution

Cloud analysis (AMP Cloud)

Analysis happens on remote cloud servers, not on the endpoint

Uses massive compute power and global threat intelligence

Can update verdicts dynamically as new data arrives

Local analysis (Legacy AV)

Analysis happens entirely on the local endpoint

Limited to the signature database stored on the device

Verdicts are static until the next signature update is downloaded

Retrospective Security (AMP)

Allows a file to run initially, then re-evaluates based on new intel

Can go back in time and show all endpoints affected by a file

Enables automated rollback and removal of the threat

Forward-only detection (Traditional AV)

If a file is missed at execution, it is never caught

Cannot show historical infections from a file

Requires manual re-scanning of endpoints to find missed threats

File Reputation (AMP)

Based on a range of factors: source, age, digital signature, prevalence

Scores files on a scale (e.g., 0-100) indicating trust level

Can evaluate files that have never been seen before

Signature Matching (Traditional AV)

Based on exact binary match to a known malware hash

Result is binary: either the file matches a signature or it doesn’t

Cannot evaluate unknown files at all

Watch Out for These

Mistake

Cisco AMP is just an antivirus software that you install once and ignore.

Correct

AMP is a cloud-managed security platform that continuously analyses telemetry, uses behavioural analysis, and provides retrospective detection. It is not passive like traditional antivirus.

Many beginners think all endpoint protection is the same—install, update signatures, scan. AMP’s cloud component and retrospective analysis are fundamentally different and often overlooked.

Mistake

AMP can detect and block all malware instantly on the first execution.

Correct

AMP may initially allow a file if its reputation is unknown. Only later, when more telemetry is analysed, may the verdict change. AMP then retrospectively rolls back the threat.

People expect instant perfection. Security is about balancing false positives and false negatives. AMP prioritises avoiding blocking legitimate software over instant blocking of unknown threats.

Mistake

AMP works only on Windows laptops.

Correct

AMP supports Windows, macOS, Linux, Android, and iOS. It also supports servers and virtual machines.

Because Cisco is strongly associated with Windows enterprise environments, beginners assume it doesn’t run on other platforms. The exam may test cross-platform support.

Mistake

Once AMP blocks a file, that file is permanently deleted from the endpoint.

Correct

AMP quarantines the file—it moves it to a secure location where it cannot execute. The file can be restored if it was a false positive. Deletion is a separate manual or policy-based action.

People confuse ‘block’ with ‘delete’. Quarantine allows recovery and forensic analysis, which is critical in enterprise security.

Mistake

AMP uses the same signature database as traditional antivirus but with more entries.

Correct

AMP uses signatures as one small part of a larger analysis that includes file reputation, behavioural analysis, and machine learning. Signatures are not the primary detection method.

Because many existing security tools market themselves as ‘next-gen’ while still relying heavily on signatures, beginners believe AMP is just an extended signature database.

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Frequently Asked Questions

Does Cisco AMP for endpoints work without an internet connection?

Yes, the AMP agent can run in offline mode using local caching of reputation data, but cloud-based features like telemetry analysis and retrospective security require internet connectivity. Without the cloud, detection relies on local signatures and behavioural rules.

What is the difference between Cisco AMP and Cisco Firepower?

Cisco AMP for endpoints is a software agent installed on individual devices (laptops, servers). Cisco Firepower is a network firewall that inspects traffic passing through it. They integrate: Firepower can forward suspicious files to AMP cloud analysis, and AMP shares threat intelligence with Firepower.

Can AMP detect ransomware?

Yes. AMP’s behavioural analysis can detect the unusual file encryption activity typical of ransomware, even if the ransomware binary has never been seen before. It can block the process and quarantine encrypted files for potential recovery.

How does AMP handle false positives?

If AMP blocks a legitimate file, the administrator can use the console to whitelist the file’s hash or set a policy exception. The file can be restored from quarantine, and AMP will learn from the feedback to reduce future false positives.

Does AMP protect endpoints that are not always connected to the corporate network?

Yes, the AMP agent works regardless of network location—office, home, or public Wi-Fi. It communicates with the cloud whenever an internet connection is available. Offline, it uses cached policies and reputation data.

What is the difference between ‘block’ and ‘quarantine’ in AMP?

Blocking prevents a file from executing but leaves it in its original location. Quarantine moves the file to a secure, isolated folder with restricted permissions, preventing it from running and making it accessible only to administrators for analysis.

Terms Worth Knowing

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